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However, several limitations exist in differentiating MSCs into Schwann-like cells, such as the requirement of special induction medium, the time-consuming process (usually taking 2 ~ 3 weeks in special induction conditions) [48], the variation in the induction efficiency, and the phenotypic instability of MSC-derived Schwann-like cells, etc

Because some researchers may not have tested the mechanisms by which drugs modulate synaptic plasticity in relation to neurexins, and some drugs with potential for sustained antidepressant effect based on the modulation of synaptic plasticity by neurexins may have been overlooked

Tukhovskaya et al

& Ahren, B