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Brain Lesions, Cerebral and Cerebellar Cortex, Hypothalamus/Thalamus, and Hippocampus Without therapy, the consistently downhill course of ligation of the bile duct at its entry into the duodenum in rats led to multiple organ lesions, widespread thrombosis, disturbed ECG and blood pressure, portal and caval hypertension, aortal hypotension, and in particular, intracranial (superior sagittal sinus) hypertension

When considering treatment effects under the assumption that all individuals adhered to the therapy1, participants administered CagriSema experienced a weight loss of 22.7% after 68 weeks, significantly exceeding the 11.8% loss with cagrilintide 2.4 mg, 16.1% with semaglutide 2.4 mg, and 2.3% with placebo