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After its synthesis, GSH is transported to the intracellular compartments, mitochondria, endoplasmic reticulum and nucleus, but most of it is released through transporters toward the extracellular space

To achieve reasonable runtimes (on the order of a few minutes for a run of several thousand iterations), the size of the search space is further constrained by placing an upper limit on the number of reactions that can be used to construct a pathway

Contraindications and precautions: Use caution in patients with a history of asthma, sulfite sensitivity, or known allergy to glutathione or any formulation components

Cells under chronic ferroptotic stress exhibited increased sensitivity not only to the ferroptosis inducer RSL-3 but also to hydrogen peroxide