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228,229 Genetic studies suggest that polymorphisms in the aldose reductase gene influence individual susceptibility to DPN, 230 highlighting the potential for personalized therapies

KPV: the anti-inflammatory tripeptide for immune modulation KPV is a tripeptide consisting of just three amino acids: lysine, proline, and valine

After first-line treatments and diagnostics, including diet change, addition of probiotics, and fecal analysis, were performed, a GI panel determined serum cobalamin, folate, and trypsin-like immunoreactivity

Conservative titration alternative Some protocols use a more gradual titration than the standard 4-week phases