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Du H, Chen B, Jiao NL, et al

Peripheral tinnitus often results from damaged hair cells in the inner ear, while central tinnitus occurs when the brain overcompensates for lost auditory input by creating its own phantom sounds

(Given the potential long-term consequences of NMOSD relapses, the company could not ethically include a direct placebo arm in its Phase III trial.) Ultomiris was well-tolerated overall, and most treatment-emergent events were mild or moderate in severity, according to AstraZeneca