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A meta-analysis summarizing 37 RCTs noted that carnitine supplementation causes a noticeable reduction in weight and up to 2 kg reduction in body fat

Additionally, Herberts model proposes the use of holotranscobalamin, the active form of vitamin B12, as a marker: a low holotranscobalamin level is believed to be a more reliable indicator of vitamin B12 impairment than a low serum vitamin B12 level

Special cases: In patients with neurological symptoms, the frequency may be initially more frequent and maintained at shorter intervals for a longer period of time

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