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6g) reveals that the backbone atoms of GSH_c experience some deviation at around 50 ns and 180 ns, stabilizing after 200 ns and maintaining this stability until 500 ns

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This is based on the role of SAM as both an allosteric activator of cystathionine -synthase and an allosteric inhibitor of MTHFR, the enzyme that produces 5-methyltetrahydrofolate (Figure 2)

Rev Prat 70:149151 Johansson E, Luoto TM, Vainionp A, Kauppila A-M, Kallinen M, Vrl E, Koskinen E (2021) Epidemiology of traumatic spinal cord injury in Finland