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Under the inducement of diverse stimuli and the activation by various cellular signals, GSDM proteins are subjected to proteolytic cleavage, and the oligomerized N-terminal domain of GSDM proteins is allowed to penetrate the cell membrane and cause rapid plasma membrane rupture, thus releasing proinflammatory mediators such as IL-18 and IL-1 [33, 65]

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The GLOW Blend's effects on collagen synthesis and extracellular matrix (ECM) organization exemplify the synergistic benefits achievable through multi-pathway activation, with each component contributing distinct mechanisms that collectively optimize both the quantity and structural quality of newly synthesized matrix proteins