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Pregnant women with the MTHFR 677TT genotype had lower serum folate levels (p = 0.042) and higher Hcy levels (p = 0.003), according to a multivariate study by Aline Barnabe et al

DIAGNOSTIC CRITERIA FOR VITAMIN B12 DEFICIENCY USED IN STUDIES ASSESSING THE VITAMIN B12 STATUS IN PATIENTS WITH T2D ON METFORMIN THERAPY Despite the diagnostic specificities of vitamin B12 deficiency and the necessity to measure biomarkers without suggestive symptoms, most studies assessing the risk of vitamin B12 deficiency in metformintreated patients rely solely on total vitamin B12 levels to confirm the diagnosis

Treatment may include rest, splinting, physical therapy, or, in severe cases, surgical intervention to relieve pressure on the nerve

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