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Oral ivermectin disposition is affected in horses by concomitant administration with antihistamines, including fexofenadine and cetirizine, which is in line with the well-known transporter-mediated interactions with systemic exposure (94, 95)

Several CoQ biosynthesis genes have been implicated in epilepsy including COQ1-PDSS2 , COQ2 , COQ4 , COQ5 , COQ6 , COQ8-ADCK3 , COQ8-ADCK4 , and COQ9 , with COQ2 , COQ4 , and COQ8-ADCK3 mutations being more frequently associated with seizures (124)

Therefore, arginine metabolism and subsequent polyamine biosynthesis play pivotal roles in regulating CD4 + T cell differentiation in disease settings

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