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[8] It removes pyruvate from peripheral tissues, promoting more efficient ATP production

MG, methylglyoxal

Unlike glucose and glutamine, which are taken up by their corresponding transporters, imported cystine must first be reduced to cysteine ( via glutaminase and serves as a precursor for GSH synthesis, in addition to a role in the tricarboxylic acid (TCA) cycle (via conversion to -ketoglutarate) ( Figure 2 Many studies indicate that several SLC7A11-high cancers are sensitive to glucose deprivation, however the exact mechanism here remains an active area of research

Additionally, an attenuation of the Apoptosis pathway was observed in a mouse model of PSO ( Figure 4B )