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Zhu, L., Qu, J., Tian, Q., Qin, S., Xu, Z., Zhang, J., Lu, C., & Li, W

A landmark analysis revealed that while approximately 86% of animal studies with positive findings proceed to human trials, fewer than 5% of those interventions achieve regulatory approval [568]

LSH, a DNA methylation modifier and a reader of 5-hmC, increases the 5-hmC levels at the promoters of the lipid metabolism-associated gene GLUT1 (glucose transporter type 1) and fatty acid desaturase genes SCD1 (stearoyl-CoA desaturase 1) and FADS2 (fatty acid desaturase 2) to activate their expression in H358 cells and PC9 cells[115, 116]