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Aberrant mitochondrial translation (mistranslation) and subsequent loss of m therefore rendered functional OXPHOS complexes essential (Fig

Operation of the pathway in vivo: unresolved issues The ascorbateglutathione pathway as understood today does not easily lend itself to the use of nuclear isotopes to estimate metabolic flux between the different reactions

However, whether the GPX4PRDX6 interaction represents a broadly conserved ferroptosis defense mechanism or is restricted to specific cellular contexts remains to be established

The multi-center, randomized, double-blind, placebo-controlled trial involved a total of 232 diabetic patients (aged 18-70 years) diagnosed with DPN and presenting with abnormal nerve conduction velocity (NCV) in at least one nerve of the extremities