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Numerous studies indicate that upon cellular entry, CDDP interacts with DNA, its primary biological target, to create PtDNA complexes

In patients with symptomatic deep vein thrombosis and pulmonary embolism undergoing treatment with fondaparinux sodium injection 5 mg (body weight less than 50 kg), 7.5 mg (body weight 50 kg to 100 kg), and 10 mg (body weight greater than 100 kg) once daily, the body-weight-adjusted doses provide similar mean steady-state peaks and minimum plasma concentrations across all body weight categories

As early as 2003, Gangemi et al

Apolipoproteins E and CIII interact to regulate HDL metabolism and coronary heart disease risk