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Phosphorylated Smad2/3 then form a complex with Smad4, which translocates to the nucleus to activate TGF- target genes, including -SMA, collagen, fibronectin, and MMPs [8] (Fig

Retrieved October 23, 2013

Factors such as rectal irritation, lesions, or recent surgery may affect the suitability of this route of administration

Rossi RE, Monasterolo G, Incorvaia C, Moingeon P, Frati F, Passalacqua G et al (2010) Lack of neo-sensitization to Pen a 1 in patients treated with mite sublingual immunotherapy