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As an intracellular selenium protein, GPx4 can directly reduce the production of peroxide phospholipids in the cell membrane [16]

Thus, the overall median time of vitamin C treatment under the Mayo Clinic trials was only 2.5 months, while the Pauling and Cameron trials treated patients for the duration of the entire study period or as long as 12 years

These findings suggest that while SAR provides partial neuroprotection after 57 weeks of treatment, targeting higher-order cognitive deficits may require longer SAR therapy to restore hippocampal and cortical connectivity, synaptic integrity, and excitatory/inhibitory balance

The preventive evaluation revealed that the serum inflammatory markers such as IL-8 and IL-6 were markedly reduced