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In research contexts, the copper content at standard dosing falls well within established physiological ranges

J Nutr (1981) 111(1):194200

Importantly, participants in the medications studies will be treated for 12 months and studied at the end of active treatment and again after a 3 month medication washout period to determine whether improvements in beta cell function can be maintained when the active intervention is no longer in place

They reported increase in bilirubin concentration thus indicating that bile is not being excreted and/or that too much hemoglobin is being destroyed and/or that the liver is not actively treating the hemoglobin, it is receiving and could therefore lead to jaundice