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The coordination polymers, composed of ferric ions and curcumin at an ultrasmall nanoscale, exhibit blood-brain barrier permeability, which can effectively scavenge free radicals, inhibit neuroinflammation and restore mitochondrial function

Multiple nuclear localization signals function in the nuclear import of the transcription factor Nrf 2

Moreover, these multi-protein complexes are continuously exposed to a GSH-depleted environment in Gclc -deficient FoB, which might alter protein folding or their targeting to the mitochondria