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Within the Bliss independence model calculation, synergy is assumed when the actual effect of the combination is greater than the expected effect, i.e., if the Bliss score is greater than 0 (40)

10.1038/33416 Nature 118 KiyamaT.ChenC

In 2016, physicist Henry Burridge of Imperial College London and mathematician Paul Linden of the University of Cambridge did an experiment that showed how sensitive the effect is to the particulars of measurement