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Furthermore, the combination of BMS-754807 and U0126 efficiently decreased the cell viability and increased cleaved caspase 3 and apoptosis in vitro and in vivo

doi: 10.3389/fnut.2023.1120293 64 StreetMEAngeliniSBernasconiSBurgioECassioACatellaniCet al

In in vivo experiments in mice, we examined whether the degree of the GPx3 level accounts for the gender differences in APAP-induced hepatic injury, and whether GPx3 mediates the 17-estradiol reduction in APAP-induced hepatotoxicity