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12 week cycle is optimal*

Other clinical trials also did not find a beneficial effect of folic acid supplementation in combination with methylcobalamin or with acetylsalicylic acid and vitamin B6 (pyridoxine) in cognition of AD or vascular dementia patients with normal Hcy or mild HHcy [105, 106]

see Chapter 3 for more details

Researchers have shown that a TFR-mediated increase in iron uptake in GCs induces the release of ROS, mitochondrial autophagy, and lipid peroxidation (108)