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10.1136/jnnp-2019-322606 19 Daz-ManeraJ.Martnez-HernndezE.QuerolL.KloosterR.Rojas-GarcaR.Surez-CalvetX.et al

Machine learning-assisted metabolomics analysis provides new possibilities for this endeavor (152)

Strikingly, however, the proteomic analysis also revealed a drastic induction in heme oxygenase-1 (HMOX1) levels, which has an important function in protecting cells from oxidative damage (Poss & Tonegawa, 1997), in cells treated with the CRBN-based PROTAC 1a or VHL-based PROTAC 2c as well as in cells treated with CCW16 only (Figs