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Given the importance of surface lipoproteins across pathogenic spirochetes, understanding the functional consequences of surface lipoprotein variation is critical for reducing the growing burden of disease attributable to this class of organisms

Phase 2 clinical trial data published in the New England Journal of Medicine showed up to 24.2% body weight reduction at 48 weeks the highest ever reported in any obesity clinical trial

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Equally important from a gerontological perspective, the SURMOUNT trials demonstrated substantial weight loss of approximately 15%20% at 72 weeks with tirzepatide, accompanied by visceral fat reduction and broad improvements in cardiovascular and metabolic risk factors, including blood pressure, fasting insulin, lipid profiles, and liver enzymes (Jastre et al., 2022)