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Three patients had renal insufficiency as the likely cause for their anemia, with serum Cr values between 3.0 mg/dL and 5.4 mg/dL

Building on our previous published work, we employed an immunopeptidomic approach to identify surface-presented mycobacterial antigens following infection of THP-macrophages with BCG or MTB ( in silico -based approach to analyze the repertoire of MHC-bound peptides present in each identified antigen, allowing us to optimize candidate antigen selection based on epitope richness

Values between 35 and 50 pmol/L are considered a gray area and should be investigated further if corresponding symptoms are present

This is an important nuance: GLP-1 therapy, including orforglipron, is primarily a metabolic intervention