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Upon dsDNA binding, cGAS catalyzes the synthesis of the second messenger cyclic GMPAMP (cGAMP), which uniquely contains a mixed 25 and 35 phosphodiester linkage conferring high stability and potent signaling capacity [97]

doi: 10.1016/j.seppur.2012.06.042 49 SilvestreMPCCarreiraRLSilvaMRCorgosinhoFCMonteiroMRPMoraisHA

Regarding this effect size, it can be observed that dietary and/or exercise can result in an absolute reduction with 2% of intrahepatic lipid, according with a relative reduction up to 70%