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Upon irradiation of laser at 990 nm, the azobenzene emitted ultraviolet and visible light to switch azo from trans to cis isomer which leads to rotation-inversions movement and release of drug DOX

It would be beneficial if compound 102 can inhibit Hv1 at the same time while activating GPX4, as both lead to the reduction of ROS and neuroprotective function

LMK235 also significantly promoted the release of MDA and Fe 2+ (Figures 4 B, C), whereas it decreased GSH (Figure 4 D)

Conversely, the interaction between ROS and the NF-B pathway also involves the activation of antioxidant gene expression, which helps protect against ROS damage [223]