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GPX4 is required for repression of both canonical CASP1- and non-canonical CASP11-mediated cleavage of GSDMD 56 , indicating that GSH-dependent antioxidant systems do not only inhibit inflammasome assembly but also limit the oxidized membrane environment that favors gasdermin pore formation

Loren Pickart estimated that toxic effects would begin at approximately 22,500 mg, which represents a 300-fold margin above effective therapeutic doses

This is normal and indicates proper copper coordination