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It is the FDAs way of flagging a substance that may present significant safety risks when used in compounding

Liu, Y.-J

Spirulina platensis in ovo injection enhanced the expression of genes associated to immunity, antioxidants, and hatchability in quail chicks ( K-strain White Cornell Leghorns and broiler chicks grown to ages of seven and three weeks, respectively, on diets containing varied concentrations (10, 100, 1,000, and 10,000 ppm) of Spirulina platensis exhibited higher body weights than control birds ( Spirulina platensis per kg of feed, Cobb broiler chickens growth performance, blood parameters, biochemical changes in serum, and microbial load could all be improved ( Dietary supplementation of Spirulina at 10g/kg of diet showed significantly higher body weight gain and, consequently, linear improvements in FCR was observed in Cobb broilers during 35 days experimental period

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