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Description

Sequence determinants of intracellular phase separation by complex coacervation of a disordered protein

In liver fibrosis models, luteolin has been demonstrated to suppress the NLRP3 inflammasome, reducing fibrogenesis and inflammation by modifying the NFB/NLRP3/caspase-1 axis [180, 181]

PMID: 31773006

the prevalence of truncating mutations at this locus, combined with the rarity of synonymous mutations, strongly indicates that RNF43 mutations have been positively selected during the evolution of EC and CRC (Figure 4) (111)