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10.1038/srep37834 Sci

The liver microsomal stability of 1D228 was significantly improved compared with Tepotinib, especially in monkey and human liver microsomes, suggesting that the compound has good metabolic stability

The placement of waters was confined to AMY 1 R:Cagri and CTR:Cagri ( N = 1) within the deep binding pocket in order to avoid over interpretation of the cryo-EM maps