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A role for GPx-1 in regulating mitochondrial oxidant output is also supported by previous studies that found liver mitochondria from GPx-1 / mice generated more hydrogen peroxide than those from wild-type mice (110)

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Pyruvate kinase M2 regulates Hif-1 activity and IL-1 induction and is a critical determinant of the warburg effect in LPS-activated macrophages

Sometimes abbreviated as AEDG after the single-letter codes for these amino acids, this sequence creates a remarkably small peptide with a molecular weight of approximately 390 daltons