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A number of natural products, such as triterpenoid saponins (Xu et al., 2018), schisandra lignans (Zhu et al., 2019), polysaccharides (Wang et al., 2018), iridoids (Shao et al., 2017), flavonoids and quinones (Darvin et al., 2018), have been shown to have protective activity against APAP-induced hepatotoxicity

Increasing plant-based food consumption may lead to lower SAA levels

Another thing to bear in mind is that some animal studies have cast doubt on NAC's ability to stimulate glutathione production and even called into question its overall safety

However, when systemic glutathione is depleted, these free radicals destroy the delicate proteins and lipid membranes of the electron transport chain itself