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Mechanism of Action IGF-1 LR3 and IGF-1 both bind to IGF-1 receptors, the stimulation of which activates pathways, including PI3K/AKT and MAPK, to bring about the following effects: Promotion of glucose uptake and subsequent utilisation Increase in energy production in cells Enhancement of glycolysis Increased protein and lipid synthesis Coordination of nutrient uptake Increase in cell proliferation and differentiation Changes in gene expression that support cell cycle progression and tissue growth

By doing so, it protects tissues from oxidative stress and supports overall cellular health

10.1189/jlb.72.1.19 9 BringmannA.PannickeT.GroscheJ.FranckeM.WiedemannP.SkatchkovS

Western blot was performed to detect the expressions of apoptotic markers cleaved caspase-3 and PARP