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The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) family of enzymes (enzyme class 1.6.3.1) generate ROS as their primary product and, therefore, have a major role in ROS homeostasis

Adult hepatologists must increase awareness of these diseases because paediatric patients are increasingly likely to reach adulthood with their native liver, and because several adult cholestatic diseases are likely associated with the same genes as PFIC