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A cytoplasmic transmembrane protein complex composed of three proteins, TonB, ExbB and ExbD, spans the periplasm and interacts with specific TBDTs

The major plant pathway is different from the animal l-ascorbate synthesis pathway that involves 10 enzymatic steps from d-glucose to l-ascorbate via the intermediate formation of GDP-d-mannose and l-galactose [3] (Figure 1a)