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Findings identify molecular signaling pathway that could enhance current MS treatments For decades, scientists have noted an intriguing similarity between a deficiency in vitamin B 12 an essential nutrient that supports healthy development and functioning of the central nervous system (CNS) and multiple sclerosis (MS), a chronic disease in which the bodys immune system attacks the CNS and which can produce neurodegeneration

Consensus docking and induced-fit docking further identified a thermodynamically favorable and stable TMLSLC25A45 complex, with TML adopting a conformation well accommodated within the channel cavity

Swiss National Science Foundation (# 31-116689 to KQD and # 310030_135736/1 to KQD and PS), National Center of Competence in Research (NCCR) SYNAPSY - The Synaptic Bases of Mental Diseases from the Swiss National Science Foundation (n 51AU40_185897 to KQD &PC), Avina Foundation, Damm-Etienne Foundation, and Alamaya Foundation

This aldehyde is produced by multiple metabolic processes in human and mammalian cells, as described below: Oxidation of methanol by alcohol oxidases Ingestion of fruits such as apples has been shown to lead to a 10-fold increase in methanol concentration in human breath (Lindinger et al., 1997)