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Notably, ROS-mediated redox signaling plays a crucial role in maintaining cellular homeostasis by modulating the activities of transcription factors, metabolic enzymes, and epigenetic modifications

FDA cites potential immunogenicity from aggregation and peptide-related impurities and states that human safety data are limited

Treg-specific MondoA knockout can induce Th17-like Treg cells to promote the initiation of cancer, indicating the important role of the MondoA-TXNIP axis in regulating the metabolism of Treg cells