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The deletion of the p53 gene alleviates the damage of HS to endothelial cells and inhibits the mitochondrial apoptosis pathway, which in turn proves that p53 translocation plays a crucial role in HS-mediated apoptosis [128]

110 Macrophage polarization refers to the process by which macrophages are stimulated by different signals in various microenvironments to change their phenotype and function

doi: 10.1186/1471-2458-8-15 45 MoroRNBorisovASSaukkonenJKhanASterlingTRVillarinoMEet al

Acknowledgements The authors would like to recognize the contribution of the specimen donors as well as the research entities who have made these analyses possible