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[DOI] [PubMed] [Google Scholar] 34

One modulates an enzyme, the other activates a receptor

However, murine studies showed no acute toxicity at doses up to 100 mg/kg over 11 weeks, and limited human pilot data through 2026 reported no serious adverse events

For context, the Mounjaro FDA prescribing information lists injection-site reactions among the documented adverse events across the SURPASS trials at roughly 3-7% uncommon but consistent enough that a methodical approach matters from day one