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Under physiological conditions, LCACs have the capacity to regulate the current amplitude and kinetics of hERG channels in the heart, which have important effects on arrhythmia [121]

Ozen M, Gungor S, Atambay M, Daldal N

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Given the permanent bidirectional communication between the brain and the other parts of the body in interoceptive networks, it would not be realistic to aim at fully disentangling the central and peripheral components of fatigue