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In response to DOX exposure, the increased autophagy is paralleling with the apoptotic level, and cell size is decreased, which are associating with the increase in ROS content

Targeting Nrf2 ubiquitination to mediate ferroptosis in lung cancer The high expression of Nrf2 is essential for the survival of lung cancer cells, thus strategies to reduce Nrf2 expression may be effective for the treatment of lung cancer, in which ubiquitination plays an important role in the Nrf2 protein degradation pathway

One wrong move, one miscalculation, and the integrity of a very delicate molecule could be compromised

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