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Blood 112(11):1094, 2008

See Homocysteine and Mild B12 Deficiency in Vegans for more info

Stimulation of IR upregulates both mitogen-activated protein (MAP)/extracellular signal-regulated kinase and phosphoinositide 3-kinases/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathways and subsequently leading to inhibiting of apoptosis and promoting cell migration and proliferation [33]