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In this study, all early and late phase markers of odonto/osteogenic differentiation were highly expressed in IGF-1-treated SCAPs with the low-expression of hsa-let-7c , but significantly downregulated in Let-7c overexpression group, indicating that hsa-let-7c was paramount to the IGF-1/IGF-1R/ hsa-let-7c axis

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TGF1 ( responsible for liver cell growth and division), E2F1 ( cell proliferation) and HMBS (catalyzes synthesis of hydroxymethylbilane synthase) were significantly up and downregulated, respectively