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Cannabis affects sleep architecture too, and although the data is less robust than for alcohol, the principle is the same: anything that flattens slow-wave sleep flattens your response

(Kelner & Montoya, 2000)) Nicotinamide nucleotides are not thought to be competent for trans -mitochondrial transport (Lewis et al., 2014)

These side effects usually become more noticeable at the start of the treatment or when the dose increases, and often improve as your body adjusts to the medication over time