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On the other hand, it cannot be excluded that the transient downregulation of TTR mRNA, encoding protein transthyretin, might negatively affect hippocampal IGF1R expression (Vieira et al., 2015), as it is known to act synergistically with IGF-1 on IGF1R activation (Vieira et al., 2016)

Small number of research groups : A limited number of research groups have conducted most studies, which may affect the generalizability of the results

Direct agitation of the immune system by the brain and indirect agitation by the nervous and hormonal systems lead to the disruption of homeostasis and the development of autoimmunity (76)

Nat Rev Clin Oncol (2020) 17:50415