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It has been shown that roGFP2 is almost fully reduced in intact tissues and that a treatment with the GSH1 inhibitor BSO or the electrophilic xenobiotic 1-chloro-2,4-dinitrobenzene led to fully oxidized state of the biosensor accompanied by decreased fluorescence intensity 52

This is in sharp contrast to GSH, which can enter cells only slowly via specific transporters

Les scientifiques du Luxembourg Institute of Health (LIH) dcryptent ici, chez la souris, ce mcanisme molculaire qui favorise l'activation du systme immunitaire humain : les lymphocytes T, ces globules blancs du systme immunitaire luttent efficacement contre les agents pathognes la condition que le gne Gclc soit correctement exprim dans la cellule