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3: 38 (a) the nanoparticles that are not targeted could be identified by the mononuclear phagocyte system available in blood circulation and bone marrow and in organs like the spleen, lung, and liver, 39 (b) due to the hydrophobicity of nanoparticles, there might be greater adsorption of blood constituents onto the nanoparticle shell, (c) prolonged circulation duration of the nanoparticle is a requirement for in vivo injection till it gets to the area of the target, and (d) when it comes to drug targeting, atypical cell assembly can hinder the increased permeability and retention (EPR) effect, resulting in less effective drug internalisation