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Overall, the persistent OS environment maintained by the E-P-OS network confers a clonal growth advantage to fibroid cells by inducing specific mutations in key genes such as MED12 and promoting genomic instability

Furthermore, the specific induction of HO-1 had a protective effect in diabetic mice suffering from myocardial ischemic injury [97]

Individual tolerability and response vary based on baseline glutathione status, nutritional cofactors (B6, B12, folate), and genetic variations in the enzymes that synthesize or recycle glutathione