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Once the tumour became arrested in the palbociclib-treated group, mice were further randomized to receive either RSL3 (50 mg kg 1 , five times per week for 2 weeks) or the vehicle, resulting in four experimental groups: vehicle, RSL3, palbociclib and palbociclib + RSL3

& Nakane, A

Carbonyls and methylglyoxal formed through the breakdown of lipid hydroperoxide and non-enzymatically by glycolysis respectively, which can both lead to the generation of carbonylation of protein and glycation