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Mechanistically, E-Ant-S-GS suppressed the expression of HMGB1 and PAR1, key mediators of inflammation and endothelial damage, thereby attenuating systemic inflammation and acute lung injury (Kono et al., 2012)

7), revealing ORP5 as a previously unrecognized PA transfer protein that couples LD biogenesis to mitochondrial lipid metabolism and dynamics

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However, it remains challenging to explore how the expression of these RLKs is induced under these stresses